The Brain and Addiction: Insights from Dr. Mark Thomas
It's been much harder to understand how that dopamine response changes over time with repeated drug exposure. And so, combining that with imaging that we can do here at The University Of Minnesota, that not too many places have available magnetic resonance technology, mr imaging, to look across the entire brain, to look at kind of brain dynamics, that is, activity connecting one part of the brain to another over time. We do these kind of what we call longitudinal measurements, looking at the same subject again and again during different phases of drug exposure.
Ever wondered what really happens in the brain of someone with opioid use disorder? In this episode of 'Stigma's Toll', Eric Clemensen chats with Dr. Mark Thomas, a neuroscience professor and director of the Medical Discovery Team on Addiction. Dr. Thomas dives into the science behind how addictive drugs, especially opioids, change brain function and lead to compulsive drug use.
He sheds light on the critical role of the dopamine system, debunking the myth that drug users are simply chasing pleasure. Instead, he explains how these substances hijack brain circuits essential for self-regulation, turning addiction into a biological issue rather than a moral failing. Dr. Thomas also discusses his team's cutting-edge research, including neurostimulation as a promising treatment option to combat addiction relapse.
This episode is a must-listen for anyone interested in understanding the complexities of opioid use disorder and the urgent need to reduce stigma around it.