Michael Waite

Brain Shaman

Michael Waite

  • Norah Al-Azzam: RNA and Gene-based Tools for Preventing Neurodegeneration | Episode 68

Norah Al-Azzam: RNA and Gene-based Tools for Preventing Neurodegeneration | Episode 68

Wednesday 13th March 2024

Neuroscientist Norah Al-Azzam discusses RNA and gene-based tools for preventing neurodegenerative diseases like ALS and Huntington's.
105 minutes
Informative
Engaging
Educational
Hopeful
Inspiring

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Brain Shaman
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Michael Waite
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Norah Al-Azzam on RNA Tools to Combat Neurodegeneration

Episode Overview

  • RNA and gene-based tools show promise in preventing neurodegenerative diseases.
  • Complex cellular biology concepts are explained in an accessible way.
  • Enzyme replacement therapy faces challenges like crossing the blood-brain barrier.
  • Educating oneself on brain health is crucial.
  • Translating lab discoveries into clinical treatments involves significant hurdles.
We literally made a San Felipe mouse model in the lab because enzyme replacement therapy never crossed the blood-brain barrier
Ever wondered how cutting-edge science can help prevent neurodegenerative diseases? In this episode of Brain Shaman, Michael Waite chats with neuroscientist Norah Al-Azzam about the groundbreaking potential of RNA and gene-based tools in tackling conditions like ALS, Huntington's disease, and Spinal Muscular Atrophy (SMA). Al-Azzam shares her journey from political science to neuroscience, inspired by a seminar on meningitis research. She explains complex concepts in cellular biology, making them accessible and engaging.
You'll hear about the pivotal roles played by RNA, proteins, and sugars in these diseases, and the innovative diagnostic and therapeutic tools being developed. Al-Azzam also discusses the challenges of translating lab discoveries into clinical treatments and the importance of educating oneself on brain health. This episode is a fascinating dive into the world of neurodegenerative research, offering both scientific insights and practical advice for maintaining brain health.
If you're curious about the future of brain science and how it might one day prevent debilitating diseases, this conversation is a must-listen.