American Society of Addiction Medicine
American Society of Addiction Medicine
Lead: Psilocybin desynchronizes the human brain
Lead: Psilocybin desynchronizes the human brain
Lead: Psilocybin desynchronizes the human brain
Tuesday 30th July 2024
Explore psilocybin's effects on brain connectivity, prenatal cannabis use, opioid use disorder, and more in this episode of 'This Week in Addiction Medicine from ASAM'.
5 minutes
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Get the buttons here!Psilocybin's Impact on Brain Connectivity and More: A Deep Dive into Addiction Medicine
Episode Overview
- Psilocybin disrupts functional connectivity in the brain more than methylphenidate.
- Prenatal cannabis use linked to various maternal health outcomes.
- Approximately 27% of adults used prescription opioids last year; 12% misused them.
- Different patterns of psychotic symptoms are associated with substance use.
- Shared genetics between ADHD and cannabis use disorder could inform early interventions.
Psilocybin massively disrupted functional connectivity in the cortex and subcortex, causing more than threefold greater change than methylphenidate
Curious about how psilocybin affects the brain? This episode of 'This Week in Addiction Medicine from ASAM' dives into groundbreaking research on the subject. The study, published in Nature, tracked individual brain changes with precision mapping, revealing that psilocybin disrupts functional connectivity in the cortex and subcortex. These changes are more than three times greater than those caused by methylphenidate, leading to brain desynchronization across various scales.
The discussion also touches on the potential therapeutic effects of psychedelics, including persistent reduction in hippocampal-default mode network connectivity. But that's not all! The episode also covers a study from JAMA Internal Medicine exploring the complex relationship between prenatal cannabis use and maternal health outcomes. With findings ranging from increased risks of gestational hypertension to reduced risks of gestational diabetes, the study underscores the need for continued research.
Additionally, you'll hear about the prevalence and characteristics of prescription opioid use disorder (POD) in the U.S., based on data from the 2021 National Survey on Drug Use and Health. The episode also delves into the long-term effects of cannabis and stimulant use on psychosis, with a study highlighting different patterns of psychotic symptoms. Lastly, there's a fascinating discussion on the shared genetics of ADHD and cannabis use disorder, suggesting a genetic predisposition that could inform early interventions.
Whether you're a medical professional or someone interested in addiction science, this episode is packed with valuable insights.